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教师简介

黄健
作者:管理员 来源:澳门新葡亰手机版 时间:2016-12-26 09:17:05 阅读量:

职称职务:教授
学科专业:生物化学
研究方向:肿瘤生物学、神经生物学
实验室位置:澳门新葡亰5105
实验室电话:68753582
Email: jianhuang@whu.edu.cn



学习经历
1986-1990年 澳门新葡亰手机版 生物化学专业 获学士学位
1993-1996年 澳门新葡亰手机版 生物化学专业 获硕士学位
1996-1999年 澳门新葡亰手机版 微生物学专业 获博士学位


主要工作经历与任职情况
讲 师 1999-2001年 澳门新葡亰手机版
助 研 1999-2000年 香港理工大学应用生物及化学学系
博士后 2001-2003年 美国肯塔基大学生物化学学系
副教授 2001-2009年 澳门新葡亰手机版
教 授 2009-现 在 澳门新葡亰手机版

主要社会兼职

湖北省生物物理学会理事长(2012-2018)
湖北省神经科学学会理事会常务理事(2017-2022)



主要研究领域与兴趣
1.抗肿瘤药物筛选及其抗肿瘤机制的研究。

2.阿尔兹海默症发病机制以及雌激素神经保护的研究。


承担课程(本科生、研究生)
1. 主讲《生物化学技术原理极其应用》(本科生)。
2. 主讲《专业文献研读》(本科生)。
3. 主讲《神经生物学》(研究生)。
4. 教材《生物化学技术原理极其应用》第五版,副主编,科学出版社。

主持课题项目
国家自然科学基金面上项目(31870786)
国家自然科学基金面上项目(31371331)
国家自然科学基金面上项目(30970914)
国家自然科学基金二个基地项目(30740420548)
国家自然科学基金面上项目(30670647)
湖北省自然科学基金(2007ABA115)
湖北省自然科学基金(2006ABA219)
湖北省科技攻关计划项目(2006AA301B31)
湖北省高等学校教学研究项目(20062022)
教育部留学回国人员科研启动基金(2004527)


代表性论文(*通讯作者)
1.Jun Wu, Jing Yan, Pingping Fang, Hai-bing Zhou, Kaiwei Liang∗, Jian Huang∗. Three-dimensional oxabicycloheptene sulfonate targets the homologous recombination and repair programmes through estrogen receptor α antagonism. Cancer Letters 469: 78–88. (2020).


2.Pan Huang, Nan Zheng, Hai-bing Zhou, Jian Huang*. Curcumin inhibits BACE1 expression through the interaction between ERβ and NFκB signaling pathway in SH-SY5Y cells. Molecular and Cellular Biochemistry. 1-13. (2020).


3.Yue Zhao, Chenxi Zhao, Jin Lua, Jun Wu, Changhao Li, ,Zhiye Hu, Wei Tian, Liang Yang, Jin Xiang, Haibin Zhou, Zixin Deng, Jian Huang∗, Kui Hong∗. Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader, Pharmacological Research. 146: 104294. (2019).


4.Wei-Shuo Fang, De-yang Sun, Shuang Yang, Chen Cheng, Katrin Moschkec, Tianqi Li, Shanshan Sun, Stefan F. Lichtenthalerc, Jian Huang, YinghongWang*. Discovery ofa series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR. Bioorg Chem. 92:103253. (2019).


5.Zhiye Hu, Yuanyuan Li, Baohua Xie, Wentao Ning, Yuan Xiao, Yuan Huang, Chenxi Zhao, Jian Huang*, Chune Dong*, Hai-Bing Zhou*. Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displayingimproved estrogen receptor α degradation activity. Eur J Med Chem. 8;182:111605. (2019).


6.Yong Wei, Jiawei Zhou, Jun Wu, Jian Huang*. ERβ promotes Aβ degradation via the modulation of autophagy. Cell Death Dis. 10(8):565. (2019).


7.Yong Wei, Jian Huang*. Role of estrogen and its receptors mediated-autophagy in cell fate and human diseases. The Journal of Steroid Biochemistry and Molecular Biology. 191, 105380. (2019).


8.Yong Wei, Can Huang, Haoyu Wu, Jian Huang*. Estrogen Receptor Beta (ERβ) Mediated-CyclinD1 Degradation via Autophagy Plays an Anti-Proliferation Role in Colon Cells. Int J Biol Sci. 15(5):942-952. (2019).


9.Yuanyuan Li, Silong Zhang, Jing Zhang, Zhiye Hu, Yuan Xiao, Jian Huang, Chune Dong, Shengtang Huang, Hai-Bing Zhou*. Exploring the PROTAC degron candidates: OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs) chains as novel selective estrogen receptor degraders (SERDs). European Journal of Medicinal Chemistry.172 48-61. (2019).


10.Wentao Ning, Zhiye Hu, Chu Tang, Lu Yang, Silong Zhang, Chune Dong, Jian Huang, and Hai-Bing Zhou*. Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. J Med Chem. 61(18):8155-8173. (2018).


11.Jing Dong, Nan Zheng, Xue Wang, Chu Tang, Yan ping*, Hai‑Bing Zhou*, Jian Huang*. A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer. Eur J Pharmacol. 828:67-79. (2018).


12.Junjie Luo, Zhiye Hu, Yuan Xiao, Tongxin Yang, Chune Dong, Jian Huang and Hai-Bing Zhou. Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy. Med. Chem. Commun. 8(7): 1485-1497.(2017).


13.Yuzhi Lu, Jun Li, Chun-E Dong, Jian Huang, Hai-Bing Zhou,Wei Wang. Recent advances in gossypol derivatives and analogs: a chemistry and biology view. Future Med Chem. 9(11):1243-1275.(2017).


14.Lu Yang, Zhiye Hu, Junjie Luo, Chu Tang, Silong Zhang, Wentao Ning, Chune Dong, Jian Huang ,Xianjun Liu, Hai-Bing Zhou. Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy. Bioorg Med Chem.1;25(13):3531-3539.(2017).


15.Lijuan Deng, Chen Cheng, Jun Wu, Caihua Wang, Hai‑Bing Zhou*, Jian Huang*. Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells. Neurochem Res. 42(8):2246-2256.(2017).


16.Xue Wang, Nan Zheng, Jing Dong, Xuming Wang, Lijiang Liu, Jian Huang. Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells. J Steroid Biochem Mol Biol. 171:318-327.(2017).


17.Silong Zhang, Zhiyong Wang, Zhiye Hu, Changhao Li, Chu Tang, Kathryn E. Carlson, Junjie Luo, Chune Dong, John A. Katzenellenbogen, Jian Huang* and Hai-Bing Zhou*. Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands. Chem Med Chem. 12(3):235-249.(2017).


18.Huiping Xie, Zhimin Xiao and Jian Huang. C6 Glioma-Secreted NGF and FGF2 Regulate Neuronal APP Processing Through Up-Regulation of ADAM10 and Down-Regulation of BACE1, Respectively. J Mol Neurosci. 59(3):334-42. (2016).


19.Changhao Li, Chu Tang, Zhiye Hu, Chenxi Zhao, Chenlu Li, Silong Zhang, Chune Dong, Hai-Bing Zhou∗ and Jian Huang∗. Synthesis and structure–activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy. Bioorg Med Chem. 24(13):3062-74. (2016).


20.Can Huang, Peng Yuan, Jun Wu and Jian Huang∗. Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells. Neuroscience. 319: 9-22. (2016).


21.Chu Tang, Changhao Li, Silong Zhang, Zhiye Hu, Jun Wu, Chune Dong*, Jian Huang* and Hai-Bing Zhou*. Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer. J Med Chem. 58(11):4550-72. (2015).


22.Dan Tong, Janice Ortega, Christine Kim, Jian Huang, Liya Gu, Guo-Min Li. Arsenic Inhibits DNA Mismatch Repair by Promoting EGFR Expression and PCNA Phosphorylation. J Biol Chem. 290(23): 14536–14541. (2015).


23.Huijun Zeng, Pan Huang, Xue Wang, Jun Wu, Min Wu, Jian Huang*. Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells. Neuroscience. 294:172-81. (2015).


24.Nan Zheng, Peng Yuan, Changhao Li, Jun Wu, Jian Huang*. Luteolin Reduces BACE1 Expression through NF-κB and Estrogen Receptor Mediated Pathways in HEK293 and SH-SY5Y Cells. J Alzheimers Dis. 45: 659–671. (2015).


25.Caihua Wang, Changhao Li, Haibing Zhou and Jian Huang*. High-Throughput Screening Assays for Estrogen Receptor by Using Coumestrol, a Natural Fluorescence Compound. J Biomol Screen. 19(2):253-8. (2014).


26.Zhimin Xiao, Can Huang, Jun Wu, Li Sun, Wei Hao, Lai K. Leung, Jian Huang*. The neuroprotective effects of ipriflavone against H2O2 and amyloid beta induced toxicity on human neuroblastoma SH-SY5Y cells. Eur J Pharmacol. 721: 286–293 (2013).


27.Wenjuan Tan, Tsz Yan Wong, Yanfei Wang, Jian Huang, Lai K. Leung*. CYP19 expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells. Mol Cell Endocrinol. 15;375(1-2):106-12. (2013).


28.Nelson L. S. Chan, Jinzhen Guo, Tianyi Zhang, Guogen Mao, Caixia Hou, Fenghua Yuan, Jian Huang, Yanbin Zhang, Jianxin Wu, Liya Gu, and Guo-Min Li*. Coordinated processing of 3' slipped (CAG)n/(CTG)n hairpins by DNA polymerases β and δ preferentially induces repeat expansions. J Biol Chem. 288(21): 15015–15022, (2013).


29.Xinlong Zhang, Ziqing Zuo, Juan Tang, Kai Wang, Caihua Wang, Weiyan Chen, Changhao Li, Wen Xu, Xiaolin Xiong, Kangxiang Yuntai, Jian Huang, Xiaoli Lan, Hai-Bing Zhou*. Design, synthesis and biological evaluation of novel estrogen-derived steroid metal complexes. Bioorg Med Chem Lett. 1;23(13):3793-7. (2013).


30.Feng Li, Guogen Mao, Dan Tong, Jian Huang, Liya Gu, Wei Yang and Guo-Min Li*. The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα. Cell. 153(3):590-600. (2013).


31.Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Wenming Ren, Chune Dong, Jian Huang* and Hai-Bing Zhou*. Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells. Org. Biomol. Chem., 10: 9689. (2012).


32.Nelson L. S. Chan, Caixia Hou, Tianyi Zhang, Fenghua Yuan, Amrita Machwe, Jian Huang, David K. Orren,Liya Gu, and Guo-Min Li∗. The Werner syndrome protein promotes CAG/CTG repeat stability by resolving large (CAG)(n)/(CTG)(n) hairpins. J Biol Chem. 287(36):30151-6. (2012).


33.Hsiang-Tsui Wang, YuHu, Dan Tong, Jian Huang, Liya Gu, Xue-Ru Wu, Fung-Lung Chung, Guo-Min Li,and Moon-shong Tang∗. Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility. J Biol Chem. 287(15): 12379–86. (2012).


34.Tianyi Zhang, Jian Huang∗, Liya Gu, Guo-Min Li∗. In vitro repair of DNA hairpins containing various numbers of CAG/CTG trinucleotide repeats. DNA Repair, 11: 201–209. (2012).


35.Peng Yuan, Kaiwei Liang, Buyong Ma, Nan Zheng, Ruth Nussinov, and Jian Huang*. Multiple-Targeting and Conformational Selection in the Estrogen Receptor: Computation and Experiment. Chem Biol Drug Des, 78: 137–149. (2011).


36.Caixia Hou, Tianyi Zhang, Lei Tian, Jian Huang, Liya Gu, Guo-Min Li*. The Role of XPG in Processing (CAG)n/(CTG)n DNA Hairpins. Cell & Bioscience, 1:11-17. (2011).


37.Kaiwei Liang, Liuqing Yang, Chen Yin, Zhimin Xiao, Junjian Zhang, Yumin Liu and Jian Huang*, Estrogen stimulates degradation of {beta}-amyloid peptide by upregulating neprilysin. J Biol Chem. 285(2):935-42. (2010).


38.Zhi-Min Xiao; Li Sun; Yu-Min Liu; Jun-Jian Zhang; Jian Huang*, Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element. Journal of Molecular Neuroscience, 39:22-6. (2009).


39.Kaiwei Liang, Liuqing Yang, Zhimin Xiao and Jian Huang*, A Bipartite Recombinant Yeast System for the Identification of Subtype-Selective Estrogen Receptor Ligands. Molecular Biotechnology, 41:53–62, (2009).


40.Li-Juan Deng, Yan Xu, Jian Huang*, Developing a double-antigen sandwich ELISA for effective detection of human hepatitis B core antibody. Comp Immunnol Microb, 31: 515-26. (2008).


41.Guogen Mao, Xiaoyu Pan, Bei-Bei Zhu, Yanbin Zhang, Fenghua Yuan, Jian Huang, Mark A. Lovell, Maxwell P. Lee, William R. Markesbery, and Guo-Min Li, Liya Gu. Identification and characterization of OGG1 mutations in patients with Alzheimer’s disease. Nucleic Acids Research, 35(8):2759-66. (2007).


42.Huang, J., Guan, H., Booze, R. M., Eckman, C. B., Hersh, L.B. Estrogen regulates neprilysin activity in rat brain. Neurosci Lett. 367(1):85-7. (2004).


43.Deming Gou, Jun Wang, Li Gao, Yan Sun, Xiao Peng, Jian Huang, Wenxin Li. Identification and functional analysis of a novel Human KRAB/C2H2 zinc finger gene ZNF300. Biochimica et biophysica acta, 1676 (3):203-209. (2004 ).


44.Huang, J., Gou, D. M., Zhen, C. Y., Jiang, D. H., Mao, X., Li, W. X. Protection of xenogeneic cells from human complement-mediated lysis by expression of human DAF, CD 59 and MCP. FEMS Immunology and Medical Microbiology, 31(3):203-9. (2001).


45.Gou DM; Sun Y; Gao L; Chow LM; Huang J; Feng YD; Jiang DH; Li WX. Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo. Biochimica et biophysica acta, ,1518(3):306-10. (2001).





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公司简介

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