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教师简介

李文化
作者:管理员 来源:澳门新葡亰手机版 时间:2016-12-26 11:28:45 阅读量:
职称职务:教授、博导、“珞珈学者”特聘教授
学科专业:细胞生物学
研究方向:肿瘤信号转导及药物治疗
实验室位置:生科院4021房间
联系电话:027-68756711(O)
Email: whli@whu.edu.cn



学习经历
1992-1996 中南民族大学,学士
1999-2004 澳门新葡亰手机版,博士
2004-2008 哈佛大学医学院,博士后


主要工作经历及任职情况
1996-1999 湖北省农业科学院,实习研究员
2008-2012 澳门新葡亰手机版,副教授
2012-至今 澳门新葡亰手机版,教授


主要社会兼职
中国细胞生物学学会理事
湖北省细胞生物学会理事、秘书长
武汉市药理学会常务理事


主要研究领域及兴趣
1.原癌基因和抑癌基因在肿瘤发生发展中的信号转导及调控关系;
2.针对特定靶位点的抗癌药物分子机理研究。


承担课程(本科生、研究生)
《微生物学实验》,生科院、医学院本科生;
《人类重大疾病的研究前沿》,生科院研究生。


主持的主要科研项目
1. 主持:国家自然科学基金面上项目(81472684), 2015-2018年;
2. 主持:国家自然科学基金面上项目(81273540), 2013-2016年;
3. 主持:国家自然科学基金面上项目(81072151), 2011-2013年;
4. 主持:国家自然科学基金面上项目(30871261), 2009-2011年;
5. 主持:“教育部新世纪优秀人才”支持计划(NCET-13-0436),2014-2016年;
6. 主持:留学回国人员科研启动基金,2010-2012年;
7. 主持:国家新药创制重大专项(2011ZX09102-001-32), 2011-2013年;
8. 主持:湖北省杰出青年基金(2012FFA019),2013-2015;
9. 主持:武汉市青年科技晨光计划(200950431188), 2009-2011年。


代表性论文:(*通讯作者)
1.Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li*. Combination Therapy with Protein Kinase Inhibitor H89 and Tetrandrine Elicits Enhanced Synergistic Antitumor Efficacy. Journal of Experimental & Clinical Cancer Research. 2018, 37:114

2.Guixian Wu, Ting Liu, Han Li, Yafang Li, Dengju Li, Wenhua Li*. c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation. Cell Death Disease. 2018, 9:473

3.Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li, Wenhua Li*. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. Journal of Experimental & Clinical Cancer Research. 2018, 37(1):7

4.Ting Liu, Zhenxing Zhang, Chunjie Yu, Chang Zeng, Xiaoqing Xu, Guixian Wu, Zan Huang, Wenhua Li*. Tetrandrine antagonizes acute megakaryoblastic leukemia growth by forcing autophagy-mediated differentiation. British Journal of Pharmacology. 2017, 174:4308-4328.

5.Yicheng Chen, Chang Zeng, Yao Zhan, Haiqing Wang, Xinnong Jiang, Wenhua Li*. P85α aberrantly low expression in stromal fibroblasts promotes breast cancer cell metastasis through exosomes mediated paracrine Wnt10b.Oncogene. 2017, 36:4692-4705.

6.Zhaohua Ping, Hui Xu, Ting Liu, Junchao Huang, Yan Meng, Xiaojuan Xu*, Wenhua Li* and Lina Zhang*. Anti-hepatoma activity of the stiff branched -D-glucan and effects of molecular weight. Journal of materials Chemistry B. 2016, 4:4565-4573

7.Jiali Wan, Jia-Hong Wang, Ting Liu, Zhixiong Xie, Xue-Feng Yu, Wenhua Li*. Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo. Scientific Reports. 2015, 5:11398; doi: 10.1038/srep11398.

8.Ting Liu, Qiuxu Men, Guixian Wu, Chunrong Yu, Zan Huang, Xin Liu*, Wenhua Li*. Tetrandrine inhibits proliferation and induces autophagy mediate differentiation by activating ROS and Notch1 signaling in NB4 leukemia cells. Oncotarget. 2015, 6:7992-8006.

9.Haiqing Wang, Ting Liu, Lu Li, Qin Wang, Chunrong Yu, Xin Liu*, Wenhua Li*. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell & Bioscience. 2015 5:4.

10.Liufeng Mei, Yicheng Chen, Zhimeng Wang, Jian Wang, Jiali Wan, Chunrong Yu, Xin Liu, Wenhua Li*. Synergistic antitumor effects of tetrandrine and chloroquine combination therapy in human cancer. British Journal of Pharmacology. 2015, 172:2232–45.

11.Ke Gong, Zhenxing Zhang, Yicheng Chen,Hong-Bing Shu, Wenhua Li*. Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma. European Journal of Pharmacology. 2014, 738:142-52.

12.Yu Song, Ke Gong, Hong Yan, Wei Hong, Le Wang, Yingliang Wu, Wenhua Li*, Wenxin Li*, Zhijian Cao*. Sj7170, a serine protease peptide inhibitor from the venom of the scorpion Scorpiops jendeki, promotes tumorigenesis and metastasis of human glioblastoma cells in vitro and in vivo. Journal of Biological Chemistry. 2014, 289:11667-80.

13.Jingru Li, Yicheng Chen, Jiali Wan, Xin Liu, Chunrong Yu, Wenhua Li*. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells. British Journal of Pharmacology. 2014, 171:3182-95.

14.Jiali Wan, Ting Liu, Liufeng Mei, Jingru Li, Ke Gong, Chunrong Yu, Wenhua Li*. Synergistic antitumor activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling. British Journal of Cancer. 2013,109:342-50.

15.Yan Zhang,
Wenhua Li*, Liming Wang, Ping Shen, Zhixiong Xie. Adenosine monophosphate affects competence development and plasmid DNA transformation in Escherichia coli. Current Microbiology. 2013,67:550-6.

16.Hai-Ming Hu, Yicheng Chen, Lu Liu, Chuan-Geng Zhang, Wei Wang, Ke Gong, Zan Huang, Ming-Xiong Guo, Wen-Xin Li* and Wenhua Li*. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. FASEB Journal. 2013, 27:163-73.

17.Ke Gong, Chao Chen, Yao Zhan, Yan Chen, Zebo Huang, Wenhua Li*. Autophagy-related gene 7 (Atg7) and reactive oxygen species (ROS)/ extracellular-signal-regulated kinase (ERK) regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. Journal of Biological Chemistry. 2012, 287:35576-88.

18.Yao Zhan, Ke Gong, Chao Chen, Haiqing Wang, Wenhua Li*. p38 MAP kinase functions as a switch in MS-275 induced reactive oxygen species-dependent autophagy and apoptosis in human colon cancer cells. Free Radical Biology and Medicine. 2012, 53:532-43.

19.Ke Gong, Jia Xie, Hong Yi, Wenhua Li*. CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1-arrest, ROS-dependent apoptosis and differentiation in human leukemia cells.Biochemical Journal. 2012, 443:735-46.

20.Guan Wang, Yao Zhan, Haiqing Wang, Wenhua Li*. ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by down-regulating the Bcl-2 family of anti-apoptotic protein. Cancer Chemotherapy and Pharmacology.2012, 69:799-805.

21.Ke Gong, Wenhua Li*. Shikonin, a Chinese plant derived naphthoquinone induces apoptosis in hepatocellular carcinoma cells through Reactive Oxygen Species. A potential new treatment for hepatocellular carcinoma.Free Radical Biology and Medicine. 2011, 51:2259-7.

22.Chaoyang Liu, Ke Gong, Xin Mao, Wenhua Li*. Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. International Journal of Cancer. 2011, 129:1519-31.

23.Wenhua Li, Chin-Lee Wu, Phillip Febbo, Aria F. Olumi*. Stromally expressed c-Jun regulates proliferation of prostate epithelial Cells. American Journal of Pathology. 2007, 171: 1189-1198

24.Wenhua Li, Xiaoping Zhang, Aria F. Olumi*. MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Research. 2007, 67:2247-2255.

25.Li Wenhua, Xie Haiyan, Xie Zhixiong, Lu Zhexue, Ou Jianhong, Chen Xiangdong, Shen Ping. Exploring developing mechanism of Escherichia coli competence using quantum dots as fluorescent probes. Journal of Biochemical and Biophysical Methods. 2004, 58:59-66.

26.Li Wenhua, Zhao Ruming, Xie Zhixiong, Shen Ping. Effects of La3+ on growth, transformation and gene expression of Escherichia coli. Biological Trace Element Research. 2003, 94:167-177.

27.Li Wenhua, Liu Yi, Zhao Ruming, Xie Zhixiong, Shen Ping, Qu Songsheng.Effects of La3+ on the competence of Escherichia coli as studied by microcalorimetry. Biological Trace Element Research. 2003, 91:267-75.



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